Serum Cystatin C(Cys-C) has been proposed as a marker of glomerular filtration rate(GFR). Serum creatinine (creatinine) is widely used to estimate the glomerular filtration rate, but its tubular secretion, dependence on muscle mass, alteration in some inflammatory diseases, and analytical interferences can limit its utility. Thus, Cys-C has been proposed as a novel biomarker of kidney function.

Advantages

Reduced influences of age, gender, weight, and muscle mass compared to serum creatinine

Clinical Significance

If you have an abnormally high concentration of cystatin C in your blood, it may mean you may have a kidney condition, such as chronic kidney disease. Higher levels of cystatin C may also be caused by diabetes, cancer, HIV, hyperthyroidism, or hypothyroidism.